The combination of Metformin and Reglanate may be taken as Metformin with meals oral starting dose of 0.5g twice a day; Reglanate oral starting dose of 0.5mg 15 minutes before meals, 3 times a day, but the specific dosage of the drug and the number of times to take the drug need to be based on the blood glucose under the guidance of a doctor. Combined with the instructions, when the use of metformin alone is not enough to control blood glucose, Reglanate can be combined with metformin, and taken together can also treat patients with type 2 diabetes mellitus that can not be effectively controlled through dietary control and exercise. It should be noted that Metformin is contraindicated in severe renal failure, severe infection, severe trauma, and allergy to Metformin; Reglanat is contraindicated in allergy to Reglanat, type 1 diabetes mellitus, diabetic ketoacidosis, and severe hepatic function abnormalities. There is a possibility of hypoglycemic symptoms during the combination of drugs, causing dizziness, anxiety, sweating, hunger, and inattentive performance. Once the hypoglycemic reaction occurs, it is necessary to pay attention to it and correct the hypoglycemia in time. If the patient needs the combination of the two, it is recommended to go to the hospital, the specific dosage of the drug as prescribed by the doctor.