Most of the 40-year-old patients with osteonecrosis of the femoral head can be cured after timely removal of the cause and timely targeted treatment. Necrosis of the femoral head has more causes, and the pathogenesis is not completely clear, usually due to hip trauma, long-term heavy drinking, high-dose use of glucocorticoids or combined with decompression sickness, systemic lupus erythematosus and other diseases, and also with age, smoking, gender, obesity and other factors. Most patients can be cured after removing the causes of the disease in time and taking targeted treatment in accordance with the doctor’s instructions. However, for patients who are not actively treated or in serious condition, they need to undergo artificial joint replacement in time, which is generally more difficult to cure, and the technology can guarantee patients to use it for more than 25 years, and patients need to be followed up for a long time. Some patients with serious condition may have femoral head necrosis and collapse, leading to activity disorder, and even secondary lumbar osteoarthritis. It is recommended that 40-year-old patients with necrosis of the femoral head should seek medical treatment as soon as possible and take good care of themselves so as not to delay or aggravate their condition.