Monkeypox disease has no effective treatment, is a self-limiting disease, the treatment is mainly symptomatic supportive therapy, prevention and treatment of complications, rest, supplemental water and nutrition. 1. General treatment: strengthen nursing care, keep eyes, nose, mouth and skin clean. 2.Drug treatment (1) Antipyretic drugs: If the patient has persistent high fever and is incapable of powerlessness to reduce the fever, the application of antipyretic drugs, such as ibuprofen, etc. can be considered. (2) Antibiotics: anti-infection treatment, such as cidofovir. (3) Povidone-iodine: those who have skin breakage can apply povidone-iodine to avoid infection in the broken area. 3. Other treatments: physical cooling, when the patient has fever, consider applying ice packs, ice patches, etc. to cool down the temperature. If the patient has monkeypox disease, it is recommended to go to the hospital for symptomatic treatment in time to avoid complications.