Acne on the face during puberty may be caused by seborrheic dermatitis, folliculitis, acne and other diseases with papular manifestations, which can be treated with general therapy and medication. 1. Seborrheic dermatitis: during puberty, the oil secretion is exuberant, which can easily cause greasy scales on the patient’s skin, and red papules with itching. Can be applied locally tacrolimus ointment, clotrimazole cream and other drugs for treatment, can play an anti-inflammatory and antibacterial effect, oral vitamin B6, antihistamines such as loratadine. 2. Folliculitis: pathogenic bacterial infections can easily lead to follicular area blockage caused by red pimples, there will be severe itching and pain. Pay attention to facial cleanliness, bacterial folliculitis can be applied under the guidance of the doctor fusidic acid cream, fungal folliculitis can be used topical amorphophallus ointment and other drugs. 3. Acne: During puberty, androgen secretion will be exuberant, which will easily lead to sebaceous glands to produce more sebum that will clog pores and increase the chance of Propionibacterium acnes infection causing acne. You can apply retinoic acid ointment, fusidic acid ointment and other medications to treat acne. For patients with more severe acne, you can take oral isotretinoin and doxycycline. Patients with acne on the face during puberty need to go to a professional hospital for consultation, to clarify the cause of the disease, and then according to the cause of the cause of the cause of the treatment.