Aspartate aminotransferase 46.20 U/L may be physiologic elevation, or it may be caused by viral hepatitis, gallstones, acute myocardial infarction and other diseases, which need to be adjusted for the cause of the cause of the disease in the form of lifestyle modification, medication, surgical treatment and so on. 1. Physiological elevation: If the patient drinks alcohol, stays up late, works hard and eats greasy food in the week before the blood test, it will cause a transient elevation of aspartate aminotransferase. If viral hepatitis is excluded, it is recommended that patients actively change their daily life style, such as patients pay attention to rest, do not drink alcohol, stay up late, labor, and eat a light diet. 2. Viral hepatitis: Typical symptoms include tiredness, pain in liver area, anorexia of grease and so on. Patients need to follow the doctor’s instructions to apply antiviral drugs, such as ribavirin, polyethylene glycol interferon, etc., as well as immunomodulators such as thymic pentapeptide, and liver-protecting drugs such as magnesium isoglycyrrhizate and glutathione. For patients with severe hepatitis, surgical treatments such as liver transplantation and artificial liver support system should be considered. 3. Gallstones: common symptoms include biliary colic, nausea and vomiting. Symptomatic patients need to follow the doctor’s instructions to apply diclofenac, indomethacin and other non-steroidal anti-inflammatory analgesics, can effectively relieve pain. Patients may also be prescribed choleretic drugs such as ursodeoxycholic acid tablets and dehydrocholic acid tablets. Surgical modalities for the treatment of this disease include laparoscopic cholecystectomy, traditional cholecystectomy, and so on. 4. Acute myocardial infarction: the main symptoms include palpitations, chest discomfort, pressure in the precordial area, etc. Patients should apply mononitrate as prescribed by the doctor. Patients need to follow the medical advice to apply isosorbide mononitrate, nitroglycerin and other vasodilators, metoprolol, bisoprolol and other β-blockers, as well as simvastatin, atorvastatin and other statins to regulate blood lipids. In severe cases, percutaneous coronary intervention is needed, and if that is not effective, coronary artery bypass grafting is needed. There are many other reasons for elevated aspartate aminotransferase, so it is recommended that the patient actively consult the doctor for further examination and cooperate with the doctor to actively treat the primary disease.