There are many reasons for ankle swelling, such as cardiac insufficiency, renal insufficiency, cirrhosis of the liver, venous thrombosis of the lower extremities, and medication factors. 1. Cardiac insufficiency: patients often show shortness of breath, fatigue, dyspnea, enlarged liver, as well as urinary edema and other symptoms. 2. Renal insufficiency: it can easily lead to water and sodium metabolism disorders, thus showing subcutaneous edema, often accompanied by elevated blood pressure. If the symptoms are more serious, it may lead to left heart failure or cerebral edema. 3. Cirrhosis: patients with more serious conditions, there will be hypovitaminosis, mainly manifested as lower extremity edema or abdominal fluid. 4. Lower extremity venous thrombosis: if the lower extremity venous thrombosis develops into deep venous thrombosis, the patient’s unilateral lower extremity will have sudden swelling, redness and hot pain, and the patient will also be accompanied by superficial venous dilatation. 5. Drug factors: prolonged use of antihypertensive drugs, especially nifedipine and other calcium antagonists can easily induce different degrees of edema. Ankle swelling a press a pit, should go to the local hospital in time, clear cause, according to the doctor’s instructions for appropriate treatment.