There is a clinical tendency for right lung horizontal fissure nodules to heal spontaneously, and the need for treatment should be considered. Treatment mainly includes drug therapy and surgery. 1. Drug therapy: there is no specific drug for pulmonary nodules, and the purpose of treatment is to control disease activity and protect organ function. Commonly used drugs are adrenocorticotropic hormone and immunosuppressant, such as prednisone, cyclosporine, methotrexate, azathioprine and so on. Among them, hormones are the drugs of choice for the treatment of pulmonary nodules. Hormonal drugs have adverse reactions such as liver and kidney damage, and the use of drugs emphasizes the principle of individualization, it is recommended to use drugs under the guidance of a doctor, not blindly self-medication to avoid adverse reactions. 2. Surgery: Surgical resection can be considered for larger lung nodules that suggest malignant transformation. It is recommended that patients with horizontal fissure nodules in the right lung, go to the hospital in time and listen to the professional doctor’s advice.