Omeprazole is ineffective, the possible reasons include not symptomatic use of medication, not standardized and rational use of medication, the emergence of adverse reactions and other reasons, can be taken to replace the drug and other measures for disposal. 1. Disposal without symptomatic medication: Omeprazole is mainly used for gastroesophageal reflux, gastritis, gastric ulcer and other diseases of the antacid treatment, if not for the above purposes, may be ineffective. It is recommended to go to the hospital for examination of gastroscopy, to clarify the cause of the disease, and to use medication according to the specific cause of the disease. 2. Failure to standardize the rational use of medication disposal: omeprazole different specifications of different dosage frequency, if there is a leakage or reduce the amount of dosage, may lead to acid reflux and other symptoms of poor control; in addition, if a variety of drugs for the combined use of, such as for Helicobacter pylori infection caused by gastritis, often need to be quadruple therapy, only taking omeprazole is ineffective. It is recommended to follow the doctor’s instructions. 3. Adverse reactions: Omeprazole may cause diarrhea, nausea, abdominal pain, flatulence and other adverse reactions. It is recommended to stop using the drug and replace it with other antacid drugs. The symptoms do not improve after the medication, it is recommended to prioritize to the hospital, the clinician to make a judgment according to the specific situation.