Strong cough and tickling throat at night may be caused by allergic pharyngitis, sinusitis, reflux pharyngitis and other factors. It is recommended to pay attention to life and dietary care, and give antihistamine, anti-infection, increase gastrointestinal dynamics and other medications for the cause of the disease. 1. Allergic pharyngitis: Inhalation of allergens, such as dust and dust mites, by allergic patients may cause allergic reactions, leading to worsening of cough at night. It is recommended to change bedding and give antihistamines such as loratadine and levocetirizine if necessary. 2. Sinusitis: Sinusitis patients, if the sinus opening is narrower, ventilation, drainage function is poor, the accumulation of purulent secretions in the sinuses. The change of body position after sleeping at night, the secretion into the throat, can cause violent cough. It can be treated with nasal spray budesonide nasal spray, oral clarithromycin tablets, eucalyptus pinocin enteric soft capsule, montelukast sodium and other medications. 3. Reflux pharyngitis: excessive food intake at dinner or late-night snacks and heavy drinking lead to reflux of gastric contents into the throat, which is also the main reason for worsening cough and tickling of the throat at night. It is recommended to improve dietary habits, with domperidone, mosapride and other drugs, can increase the power of the gastrointestinal tract, reduce the reflux of gastric contents. Coughing at night and tickling in the throat, it is recommended to go to the ENT department of the hospital, first to clarify the cause before standardizing the use of medication and treatment.