Would chronic leukemia be a good candidate for cart therapy?

Chronic granulocytic leukemia is not suitable for cart therapy treatment. Chronic granulocytic leukemia is a malignant clonal proliferative disease with clinical manifestations of fever, malaise, night sweats, emaciation, hepatosplenomegaly, bone pain, bleeding and pallor. 1. The treatments for chronic stage are tyrosine kinase inhibitors, interferon-alpha, hydroxyurea and other medications, as well as hematopoietic stem cell transplantation, radiation therapy, splenectomy, etc. The accelerated and acute stages are treated with tyrosine kinase inhibitors as single agent or combined with chemotherapy (cyclophosphamide, etc.), and then receive allogeneic hematopoietic stem cell transplantation. 2. cart therapy refers to immune cell therapy, which uses autologous or allogeneic cells, including hematopoietic cells, tumor cells, or immune cells, etc., to make cell preparations through in vitro induced expansion, and then infused back into the patient’s body, so as to activate or enhance the immune function of the diseased body. It is suitable for the treatment of acute lymphoblastic leukemia, but not for the treatment of chronic granulocytic leukemia. Specific treatment should be carried out under the guidance of physicians.