Trazodone is an antidepressant, low dose has the effect of improving sleep, to be clinical symptoms are relieved can be discontinued under the guidance of a physician. Trazodone mainly acts on the 5-hydroxytryptamine receptor in the center, antagonizes its binding with 5-hydroxytryptamine and inhibits the reuptake of 5-hydroxytryptamine, thus reducing central excitability and playing a sedative-hypnotic role, and this binding is reversible, so there will not be obvious dependence. A common side effect of Trazodone is gastrointestinal reactions, such as nausea, vomiting, dry mouth, bitter mouth, epigastric discomfort, and abnormal appetite. Generally at the very beginning of taking the drug, it may be more common, usually do not need special treatment, after a few weeks of taking the drug can be relieved by themselves. The application of the drug should strictly follow the doctor’s instructions, if there are adverse reactions that are difficult to self-relieve, should immediately consult a doctor. Any drug is not recommended to stop on their own, need to be reviewed on time, under the guidance of the physician to increase or decrease the amount or gradually stop using, not blindly increase or decrease, to avoid adverse reactions.