Rheumatoid factor 110U/ml is not necessarily rheumatoid arthritis, but also seen in systemic lupus erythematosus, tuberculosis, infectious mononucleosis and other diseases. Rheumatoid factor is an important reference for the clinical diagnosis of rheumatoid arthritis, the normal reference range is 0-20U/ml, 110U/ml is significantly higher than the upper limit of the normal reference range, but the rheumatoid factor is not unique to rheumatoid arthritis, but also can be seen in systemic lupus erythematosus, tuberculosis, infectious mononucleosis and other diseases. In addition, not every rheumatoid arthritis patient test rheumatoid factor will be elevated, so although the rheumatoid factor and rheumatoid arthritis are closely related, but only by the rheumatoid factor alone can not confirm the diagnosis of rheumatoid arthritis, but also need to be combined with the patient’s physical signs, medical history, symptoms, and imaging changes and other aspects of the comprehensive analysis. Laboratory results need to be interpreted by a professional physician, it is recommended that patients with rheumatoid factor 110U/ml go to the Department of Rheumatology and Immunology of a regular hospital for detailed consultation.