Jealousy paranoia in the clinical treatment of the main choice of antipsychotic drugs systematic standardized treatment, the core clinical manifestation is the fear of their spouses or loved ones to be unfaithful to their own, so the treatment is based on antipsychotic drugs. However, relevant studies also show that a large proportion of patients’ symptoms may not be completely relieved, so the treatment should be based on minimizing the symptoms and reducing the impact of psychotic symptoms on social functioning. Clinical selection of new antipsychotic drugs as the first choice, such as the application of olanzapine, risperidone, quetiapine, aripiprazole, ziprasidone and other drugs, in the process of treatment, pay attention to the assessment of adverse reactions and therapeutic effects, and do a good analysis of the pros and cons. Then, for the patient and his family to carry out family intervention, including healthy cognitive psychoeducation, to establish a good patient’s family and caregivers of the delusional concept of cognition, to avoid confrontation and argumentation with the patient, to encourage family stability is the main focus to stabilize the patient’s mood, so that the patient’s active cooperation with the treatment as the main goal, which for the patient with jealousy delusional disorder is very important, and the treatment of its compliance is often more than the medication alone is more effective.