For androgen supplementation, there are three methods: injections, oral medications and transdermal patches. The active core of testosterone preparations is natural testosterone, and in order to enhance the activity and prolong the duration of action, various modifications and alterations are made to its chemical structure to produce a wide range of testosterone derivatives. They are basically categorized into alkanes and esters, and their duration of action is also classified into short-, medium-, and long-acting as well as mixed dosage forms. The traditional testosterone propionate and testosterone enanthate are prone to cause sharp increases and decreases in blood testosterone concentration after administration, and their application violates the normal physiological circadian rhythm of testosterone, which is prone to possible side effects and makes it difficult to achieve optimal therapeutic goals. Therefore, currently other preparations are used, such as 17β-hydroxytestosterone ester, testosterone undecanoate, 17α-methyl, 19-desmethyltestosterone, etc. These testosterone preparations have their own advantages in terms of absorption, and the side effects are relatively much milder. Contraindications to treatment include prostate cancer, breast cancer, erythrocytosis, severe sleep apnea syndrome, benign prostatic hyperplasia with severe lower urinary tract obstruction, and severe cardiac or hepatic failure, which contraindicates the use of this treatment.