Hibernation Combination is mainly composed of chlorpromazine, promethazine and pethidine, partially combined with hydrogenated synthetic ergot alkaloids, acetylpromazine and procaine to form different formulations, each with its own advantages and disadvantages. Formula I: consists of chlorpromazine, promethazine and pethidine. Used for hyperthermia and mania, but with caution in respiratory failure. Formula II: consists of pethidine, promethazine, and hydrogenated synthetic ergot alkaloids. For tachycardia. Formulation No. III: Composed of pethidine, promethazine and acetylpromazine. For high fever and irritability. Formulation No. IV: consists of promethazine and hydrogenated ergot alkaloids. For respiratory failure. Formula V: consists of promethazine, chlorpromazine, procaine. Available for oliguria; use with caution in bradycardia and arrhythmia. Hibernation Combination is a therapy mainly designed to inhibit excessive stress response, reduce metabolic rate and improve microcirculation. It is mainly used for thyroid crisis, febrile convulsions (convulsions due to high fever), tetanus, cranial injuries, severe systemic infections and so on. Specific how to use should strictly follow the clinician’s instructions to avoid adverse consequences.