Hiccups are mainly caused by diaphragmatic spasm and diaphragmatic irritation, which can be relieved by physical methods combined with medication, and there is no such thing as “the fastest and most effective”. 1. Physical methods: patients can drink a lot of water and take a deep breath to reduce hiccups by inhibiting diaphragmatic spasm. You can also pat your back to relax your diaphragm and reduce the occurrence of hiccups. 2. Drugs: Take metoclopramide and belladonna tablets as prescribed by the doctor to relieve diaphragm spasm and reduce hiccups. If the effect is not good, you can also follow the doctor’s instructions to use antibiotics, such as cefixime, levofloxacin, etc., to relieve diaphragm irritation, reduce hiccups. Patients should always consult their doctor before using medication, and avoid self-medication under the guidance of a physician.