Hard bumps on the soles of the feet may be metatarsal warts, corns or calluses, which need to be treated with medication, physical therapy, surgery, etc. for different causes. Plantar warts are caused by human papilloma virus infection, can be used externally imiquimod cream, retinoic acid cream and so on, can also apply laser treatment, electric cauterization treatment, freezing treatment and other physical methods of treatment. At the same time, we should pay attention to avoid wearing other people’s shoes and socks in daily life to cause cross-infection. Corns are caused by long-term friction and extrusion of the skin on the soles of the feet, and can be treated with topical corns cream and other medications. For large and painful corns, surgery can be performed to remove the entire corns. Usually pay attention to wear loose and soft shoes, avoid long-term walking or standing. Callus is commonly known as callus, is the local skin long-term friction caused by a kind of protective tissue, no special need can not be treated. If caused by foot deformity, need to perform surgical treatment to correct foot deformity; if there is aesthetic needs of patients, can be used externally salicylic acid ointment, retinoic acid cream. It is recommended that patients with hard bumps on the soles of their feet go to a regular hospital in time for a clear diagnosis and standardized treatment under the guidance of a doctor.