HPV 16 positive is clinically associated with high-risk HPV infection, but it is not transmitted through sexual contact, so you can have sex when you have high-risk HPV 16 infection. However, it is recommended that colposcopy should be done as soon as the infection is detected, preferably 3-7 days after menstruation and without intercourse, to find out whether the cervical epithelium has been lesioned by high-risk HPV infection and whether there is a possibility of cancer. Based on the results, the clinical decision will then be made whether treatment is needed. If the lesion is not occurring, this condition must be given regularly for examination. The vast majority of high-risk HPV types will clinically turn negative on their own after about 8-12 months, but there are still 20% of people who may have persistent infection, so regular review is very important.