Lysop, or escitalopram oxalate tablets, and Agomelatine can be used together and should be used as directed by a physician. Escitalopram oxalate tablets are a dicyclic hydrogenated phthalide derivative counterpart. It can inhibit the reuptake of 5-hydroxytryptamine by central neurons and enhance the function of central 5-hydroxytryptaminergic nerves. It can be used in the treatment of depression and panic disorder. Adverse reactions of Escitalopram Oxalate Tablets include decreased or increased appetite, weight gain, abnormal dreams, anxiety, irritability, decreased libido, insomnia, drowsiness, and dizziness. It is contraindicated for those who are allergic to this product. Agomelatine is a melatonin receptor agonist that promotes the release of norepinephrine and dopamine from the prefrontal cortex. It is used for the treatment of depression in adults. Adverse reactions include abnormal dreams, anxiety, nausea, diarrhea, constipation, vomiting, and weight gain. The drug is contraindicated in people who are allergic to the product, hepatitis B, hepatitis C, or liver impairment. Some clinical studies have shown that escitalopram oxalate tablets and Agomelatine can be used together for refractory depression, there is no drug interaction between the two, and there is no contraindication to pairing. However, the medication should be used reasonably under the guidance of a doctor.