Esophageal squamous epithelial hyperplasia with mild atypical hyperplasia is mostly benign, and can be treated with drugs such as omeprazole, mosapride, etc., with close observation and regular rechecks. Esophageal squamous epithelial hyperplasia with atypical hyperplasia is divided into three degrees of illness, mild, moderate and severe. Mild and moderate cases can be treated with drugs such as omeprazole and mosapride under the guidance of professional physicians, while severe cases need to be treated in hospitals to further improve the magnified gastroscopy and other tests to exclude the possibility of esophageal cancer, and to determine the treatment plan according to the specific situation. Patients should avoid foods containing nitrosamines, such as sauerkraut, kimchi, bacon and salami. Do not eat too hard or too hot food to avoid stimulation and damage to the esophageal mucosa. Do not drink alcohol and do not smoke, pay attention to oral hygiene, eat a balanced diet is conducive to the recovery of the disease.