Amyloidosis dermatosis, also known as mossy and patchy amyloidosis, refers to cutaneous amyloidosis, a chronic skin disease in which amyloid is deposited in normal skin tissue without involving other organs. Symptoms: amyloidosis dermatosis is common in the young adult population, with chronic onset, accompanied by severe itching; the lesions are cornified keratinized domed papules with black keratin plugs at the top. Hemispherical or polygonal, skin color or brown, rough surface, peeling off the keratin plugs to see the umbilical depression; preferred in the extension of the calf, followed by the back, behind the ears, the outer arm; occurring on the back is often a reticulate pigmented spots. Treatment: patients should go to the hospital at the onset of the disease, as prescribed by the doctor to take oral fexofenadine tablets, Avicenna capsules and other drugs to anti-allergy, promote skin metabolism treatment, but also can be applied dexamethasone ointment or carbotriol ointment, but need to be used in moderation. Nodular type can be treated by surgical excision, electrocautery, freezing, CO2 laser therapy and other methods. In addition, because its therapeutic effect varies from person to person, it is recommended that the patient according to the actual situation of the diagnosis and treatment, and the use of medication should be used under the guidance of a doctor, to avoid allergies and other adverse reactions. Usually should avoid sun exposure, in a high temperature environment, so as not to aggravate the condition.