Raised underarm hair follicles that look like chicken skin are usually referred to as perifollicular keratosis, which may be associated with autosomal dominant inheritance, vitamin A deficiency, and metabolic disorders. The lesions of perifollicular keratosis cannot be completely eliminated and can be relieved by topical or oral medications. Perifollicular keratosis can be treated with local topical exfoliators, such as 0.05% to 0.1% Vitamin A acid ointment, 3% to 5% salicylic acid ointment, 10% to 20% urea cream, etc., to soften or dissolve the keratin, and improve the symptoms; if the condition is serious, oral vitamin A, vitamin E and other drugs can be taken for treatment. It is recommended that patients with underarm follicles raised like chicken skin go to the dermatology department of a regular hospital, follow the doctor’s instructions for a clear diagnosis, reasonable medication, not blindly self-medication, so as not to cause adverse reactions and delay the condition.