Whether nodular vasculitis is serious or not is related to the clinical manifestations of the disease, the organs involved and other factors. Generally speaking, only skin plaques or nodules are not serious, but if there is skin breakdown and organ damage, it is more serious. 1. If patients with nodular vasculitis simply show skin manifestations such as benign nodules, or accompanied by reticular cyanotic spots, wind masses, purpura, blisters and other symptoms, no other organ involvement, and found that the treatment is more timely, more standardized treatment, the patient’s prognosis is also better, then the patient is relatively mild. 2. If the patient is not effectively treated and controlled in the early stage of the disease, resulting in skin ulceration, the formation of necrotic ulcers, or serious symptoms or organ manifestations, such as blindness, hearing impairment, renal artery and mesenteric artery obstruction, coronary artery stenosis, etc., and in severe cases, there may be organ failure, then it is a more serious situation. Nodular vasculitis, need to consult the hospital rheumatology and immunology department, by the doctor diagnosis and treatment of the disease, follow the doctor’s instructions.