A vague pain in the middle of the chest cavity should first be examined with an electrocardiogram, and a CT scan of the chest is needed. Because the common diseases are diseases of the cardiac system, or diseases of the lung tissue and mediastinal diseases. Because myocardial ischemia can cause chest pain, but also chest tightness, palpitations, timely administration of nitroglycerin, the patient’s symptoms can improve or even disappear. For patients with chest lung tissue infections, there will also be coughing, sputum, and chest pain. There will also be a limitation of deep breathing, especially combined with pleural effusion or complication of pneumothorax, in the anti-infective treatment at the same time need regular review, if necessary, need to choose surgical treatment. Other patients are due to mediastinal diseases, commonly mediastinal space-occupying lesions, including cysts, thymoma, and thymic hyperplasia, which can lead to chest pain, and in severe cases, further open heart surgery is needed.