Low-grade intraepithelial neoplasms of the colon are precancerous lesions that are mild to moderate atypical proliferations of the colon and can progress to colon cancer.
Epithelial intraepithelial neoplasia is a special stage before the development of epithelial malignancy, which is markedly altered from normal tissue in cell morphology and cell arrangement, biologically aggressive, and involves atypical hyperplasia or heterogeneous proliferation of epithelial tissue in multiple systemic organs (including digestive system, genitourinary system, etc.).
There is a 2-grade method for grading intraepithelial neoplasia and a 3-grade method. The 2-grade method is divided into low-grade and high-grade intraepithelial neoplasia, which corresponds to mild to moderate atypical hyperplasia and severe atypical hyperplasia; the 3-grade method is divided into 1-grade, 2-grade, and 3-grade, which corresponds to mild atypical hyperplasia, moderate atypical hyperplasia, and severe atypical hyperplasia.
Low-grade intraepithelial neoplasms of the colon are precancerous lesions such as mild and moderate atypical hyperplasia of the colon, such as colonic adenomas, with histologic and cytologic heterogeneity. Colon low-grade intraepithelial neoplasia is clinically asymptomatic, usually diagnosed by biopsy taken at colonoscopy and sent for pathological examination, and is closely related to colon cancer, 80% of which originates from colon intraepithelial neoplasia.