There is no fastest solution for impetigo. Usually, it needs to be treated with general treatment, topical medication, oral medication, etc., depending on the condition. 1. General treatment: It is recommended that patients be simply isolated from the disease and that contaminated clothing and the environment be disinfected in a timely manner to reduce the spread of the disease. 2. External drug treatment: for pustules not broken, can be used 10% glycerite lotion treatment; pustules larger, need to extract the blisters treatment; if the pustules have broken, you can use 1:5000 potassium permanganate solution or 0.5% neomycin solution to wash the wet compresses; the use of mupirocin ointment and other antiseptic and anti-inflammatory treatment. 3. Oral drug treatment: For those with generalized lesions and serious systemic symptoms, antibiotic treatment, such as penicillin and erythromycin, etc., is needed; attention should be paid to the balance of water and electrolytes, and plasma or human blood gammaglobulin should be infused if necessary. It is recommended that patients diagnosed, according to the symptoms of timely to the regular hospital dermatology, follow the doctor’s instructions reasonable treatment, the use of drugs, strictly comply with the doctor’s instructions to use drugs, not blindly self-medication.