There are many causes of high anion gap, and different causes lead to different medications for treatment. If metabolic acidosis, drugs such as sodium bicarbonate injection or sodium lactate can be chosen for treatment. If diabetic ketoacidosis, you can choose isotonic sodium bicarbonate or insulin and other drugs for treatment. 1. If metabolic acidosis, you can take drugs such as sodium bicarbonate injection and sodium lactate under the guidance of physicians, which is conducive to the regulation of water-electrolyte disorders, acid-base balance disorders, in order to achieve the purpose of treating metabolic acidosis. 2. If diabetic ketoacidosis, isotonic sodium bicarbonate and insulin can be used under the guidance of physicians to effectively correct the water and electrolyte balance and lower blood sugar to relieve symptoms. Symptoms of high anion gap, should promptly seek medical attention, clear diagnosis, targeted treatment under the guidance of the doctor, the drug should be used in accordance with medical advice.