Escherichia coli is the main causative agent of recurrent urinary tract infections and recurrent gastrointestinal infections. The recurrence of Escherichia coli generally requires symptomatic antibiotic treatment, such as levofloxacin, chloramphenicol, kanamycin and so on. Generally, recurrent episodes of Escherichia coli occur due to inadequate prior treatment, low autoimmunity, and re-infection with the bacteria. If it is a recurrent bacterial attack in the urinary tract, it is necessary to review the mid-range urine bacterial culture, and according to the drug sensitivity results of the urine bacterial culture, the anti-inflammatory treatment of full dose and long course, such as levofloxacin, has a good effect on the infection of the urinary system. If recurrent gastrointestinal infections with Escherichia coli occur, the main symptoms are watery diarrhea, abdominal pain, nausea, low-grade fever, or a small amount of mucus or even blood in the stool. Antibiotic treatment is usually performed, and chloramphenicol, gentamicin, and kanamycin may be preferred. When there is a recurrence of infection caused by Escherichia coli, do not self-medicate, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor for targeted treatment.