Pregnancy with corpus luteum is normal. The corpus luteum is the follicular fluid outflow after ovulation, the follicular cavity internal pressure decreases, the follicular wall collapses, forming many folds, the follicular wall of the follicular granulosa cells and follicular endothelial cells invade inward and the surrounding connective tissue. When the discharged egg is fertilized, the corpus luteum may enlarge under the action of human chorionic gonadotropin secreted by embryonic trophoblasts to form the gestational corpus luteum, which usually degenerates in the third month of pregnancy. The gestational corpus luteum is very important for pregnant women and babies. The gestational corpus luteum can secrete estrogen and progesterone to maintain the continuation of pregnancy and to ensure the normal development of a fertilized egg. Insufficiency of the corpus luteum before the third trimester of gestation can lead to miscarriage. The corpus luteum degenerates after the third trimester and its function is replaced by the placenta. Therefore, pregnancy with corpus luteum is a normal phenomenon, pregnant women with abnormal enlargement of corpus luteum or corpus luteum insufficiency in pregnancy, etc., should go to the hospital in time for consultation and timely treatment.