Desiccation, or dry syndrome, is a systemic autoimmune disease that predominantly invades the salivary and lacrimal glands; it is a chronic condition, and treatment for diagnosed dry syndrome generally requires lifelong therapy. Dry syndrome may be associated with infections, sex hormones, and abnormal activation of the immune system, in addition to genetically inherited factors that may lead to an increased risk of developing the disease. Patients often present with dry mouth, loss of small pieces of teeth, dry eyes, and photophobia. Patients should avoid excessive eye use, avoid prolonged exposure to dry environments, drink more water, gargle frequently, brush teeth diligently, and maintain oral hygiene. Patients with dry eyes may use artificial tears, etc. Intravenous gammaglobulin and plasma exchange can be used in severe cases. When dry syndrome occurs, it is recommended to consult a doctor in a timely manner, follow the doctor’s instructions for further examination, targeted treatment with the help of the doctor, and regular review and follow-up, ready for a long period of treatment.