A large difference in myopia between two eyes can be handled by wearing eyeglasses and surgical treatment. 1. Wearing eyeglasses: If the difference between the two eyes is less than 200 degrees, the eyes and the brain can integrate the images, then you can wear frames to correct it. However, if the difference is more than 250 diopters, the eyes and the brain can not integrate, in this case contact lenses are more suitable. 2. Surgical treatment: Adults with a large difference in myopia between both eyes can consider laser surgery to correct myopia, after laser correction, both eyes can achieve a balanced and consistent vision, and better image fusion. In addition, IOL implantation can also be considered to improve the refractive error of both eyes and balance the vision of both eyes. It is recommended to treat myopia with a large discrepancy between the two eyes in a timely manner in order to avoid abnormal consequences such as strabismus.