Itchy calves after high saphenous vein ligation may be due to numbness in the skin of the calf as a result of damage to the saphenous nerve caused by the surgery. It may also be caused by a localized skin infection. Saphenous vein high ligation is used to treat patients with varicose veins of the lower limbs, which are common in people who work in a standing position for long periods of time, with high intensity of physical activity and in sedentary people. The main causes are soft vein walls, defective valves and elevated pressure in the superficial veins. And the more centrifugal the veins are, the higher the venous pressure is, so varicose veins are more pronounced in the lower legs than in the thighs. If the legs continue to itch without relief you need to seek immediate medical attention to check for damage to the saphenous nerve. If it is due to an infection, please do not take any unauthorized medication and follow your doctor’s instructions so as not to aggravate the skin infection or cause other damage.