The dangers of herpes simplex virus type 2 infection include lifelong carriage of the virus, periodic genital herpetic injuries, increased risk of HIV-1 transmission, and an increased risk of cervical cancer. Primary infection with herpes simplex virus type 2 is primarily sexually transmitted and causes genital herpes, which manifests as blisters in the genital area that rupture and form ulcers, and complications that include extragenital injuries and aseptic meningitis. Once infected with herpes simplex virus type 2, one can carry the virus for life and experience periodic genital herpetic lesions. In addition, herpes simplex virus type 2 infection increases the risk of HIV-1 transmission as well as cervical cancer. Prevention of herpes simplex virus type 2 should focus on blocking the transmission route, avoiding close contact with the patient as much as possible, avoiding stimulation of the body by harmful factors, and actively exercising to improve the body’s immunity.