Cervical anastomotic fistula is the most serious complication after radical esophagectomy for esophageal cancer with three incisions, and patients often show increased drainage fluid from chest cavity, change of trait, elevated body temperature, respiratory difficulty and even infectious shock, and it is also one of the main causes of perioperative death in patients with esophageal cancer. Fistula that occurs within 3 days after surgery is called early fistula, which is mainly manifested by the increase of drainage fluid from patient’s drainage tube, change of dark green color of drainage fluid, and increase of body temperature. The fistula that occurs from 4 days to 2 weeks after the operation is called middle stage fistula, which is most common in 7~10 days, and the patients often have elevated body temperature, respiratory distress, and even symptoms of infectious shock, and the drainage tube drainage fluid is pus and blood change. More than 14 days after surgery, the fistula is called late fistula, mostly due to the drainage around the anastomosis is not smooth secondary infection, the anastomotic fistula is small, smooth drainage, healing is better. Once clinically found anastomotic fistula, need to actively treat, promote healing, so as not to delay the condition.