Small holes on the soles of the feet are mainly seen in the clinic for fossa keratolysis, and the treatment mainly includes drug treatment, strengthening skin care and dietary modification. 1. Drug treatment. Fossa keratolysis is a bacterial infection that occurs in the skin of the soles of the feet, mainly manifested in the soles of the feet similar to the crater of the small pits, in the treatment of the choice of topical erythromycin ointment, mupirocin ointment, clindamycin phosphate gel, and other antibiotic treatment. 2. Strengthen skin care. Pay attention to keep the foot skin clean and dry, choose loose, breathable cotton shoes and socks. 3. Diet regulation. Take some food rich in vitamins, minerals and high quality protein, which can help strengthen the body and reduce the chance of infection. For the more serious symptoms of fossa keratolysis, must be under the guidance of the doctor for standardized treatment. All of the above medications should be used under a doctor’s supervision.