Women with syphilis have more symptoms as the disease is staged. Stage I may have localized symptoms such as a hard chancre, stage II may have systemic symptoms such as a syphilis rash, and stage III syphilis may have skin and mucous membrane damage and other symptoms. 1. Stage 1 syphilis: Generally, women will have a hard chancre and swollen lymph nodes 2 to 3 weeks after infection. The chancre is mainly a red spot on the labia, perineum and cervix, which can become necrotic and is usually painless. 2. Stage 2 syphilis: usually 3 to 4 weeks after the hard chancre has subsided, a syphilitic rash of red and reddish-brown spots and macules may appear, and there may be mild itching. Pustules may appear on the skin and ulcers may appear in the mouth, throat and genitals. With the aggravation of the disease, patchy hair loss, vision loss and many other manifestations may occur. 3. Stage III syphilis: If the disease is not treated in time and enters the stage of stage III syphilis, there will be nodular syphilis rash, syphilitic tumors and other skin damages. It may also involve the cardiovascular system and nervous system, resulting in chest pain, dyspnea, headache, mental anomalies and other manifestations. It is recommended that patients should seek timely medical treatment when abnormal symptoms occur, so as to clarify the diagnosis and take targeted treatment measures.