The long-term side effects of the New Crown vaccine have yet to be observed and researched. Adverse reactions such as allergy, localized redness and swelling may be present at the time of vaccination, and there are no gender or age differences in adverse reactions. Adverse effects of XKV include redness, swelling, heat and pain at the injection site, as well as systemic adverse effects such as headache, fever and fatigue. The reactions were mild and transient, and most of them did not require special treatment and could subside on their own. There is no gender difference in the statistics of the adverse reactions. A small number of patients with severe allergy to the vaccine may experience severe discomfort such as respiratory distress, so they should be kept under observation for 30 minutes after vaccination. Xin Guan vaccine has been on the market for a large number of clinical trials to prove its good safety, so in order to control the spread of the epidemic, if there is no relevant contraindication, it is recommended to cooperate with the epidemic prevention and control of the whole vaccination.