The causes of intercostal nerve pain include herpes zoster virus infection, tumor compression, thoracic spine tuberculosis, etc. The treatment includes medication, physical therapy, nerve block, nerve destruction, etc. The medication should be used in accordance with the doctor’s prescription. 1. Herpes zoster virus infection: Herpes zoster virus is a kind of neurophilic virus, which causes intercostal neuralgia by eroding the intercostal nerves, and antiviral treatment can be given, such as the use of acyclovir and so on. Selective thoracic paravertebral nerve block under ultrasound guidance and herpes zoster area can also be injected with lidocaine and other drugs such as closed treatment. Transcutaneous electrical stimulation and local physical therapy also have certain analgesic effect. 2. Tumor compression: For example, the tumor embolus of lung cancer can be transferred to the spine and ribs through vertebral vein system, causing persistent pain, i.e. intercostal neuralgia, which can be treated by means of chemotherapy, radiotherapy, etc. At the same time, non-steroidal anti-inflammatory drugs, such as ibuprofen, etc., can be used to alleviate the pain. Chemotherapy drugs such as cisplatin can be used to relieve pain. 3. Tuberculosis of thoracic vertebrae: regular anti-tuberculosis treatment, such as isoniazid and rifampicin. Vertebral body destruction is too serious and requires surgical treatment. If the pain is severe, nerve destruction treatment is feasible. Intercostal nerve pain patients are advised to go to the hospital in time to listen to the advice of professional doctors.