Cleaning the glans with toothpaste has certain disadvantages and it is recommended not to apply toothpaste on the glans. Toothpaste contains irritating ingredients that can cause an irritating reaction or allergic reaction to the local mucous membrane of the glans, resulting in itching, pain, redness, swelling and red spots on the glans and even the penis. Many men think that toothpaste can reduce the sensitivity of the glans, this approach is not scientific, the glans appears too sensitive in the case, must go to a professional hospital consultation, through the relevant examination to clarify the cause of early treatment. To reduce glans sensitivity, you can use local anesthetics, such as lidocaine hydrochloride gel applied to the glans, or oral medications, such as paroxetine hydrochloride tablets and sertraline tablets taken orally before sexual intercourse. Sometimes the increased sensitivity of the glans is caused by overcircumcision or circumcision, which requires circumcision surgery to be able to fully expose the glans, and the sensitivity will decrease, and it is not recommended to use toothpaste to wipe the glans.