A depressed fracture of the skull can be treated conservatively. If the depression is deeper, surgery is recommended. A depressed skull fracture is one of the more common types of skull fractures. If the depression is small and there is no brain tissue damage or visible trauma, it can be treated conservatively. Usually, to avoid intracranial hemorrhage, drugs such as tranexamic acid and tranexamic acid can be used for prevention. Meanwhile, in the early stage of fracture, cold compresses are used to relieve swelling, and drugs such as aspirin and rofecoxib are used to relieve pain. However, if the depression is large, or if brain tissue damage occurs, timely surgery should be performed to avoid triggering epilepsy, such as cranial osteoplasty. The treatment of depressed skull fracture is related to the severity of the condition. Therefore, it is important to seek medical treatment after the fracture and follow the doctor’s instructions. Medications should be used under the supervision of a doctor.