Blisters on the feet after chemotherapy may be caused by foot infections after chemotherapy, or may be caused by the skin side effects of chemotherapy drugs, or may be caused by the patient’s allergy to chemotherapy drugs. 1. Post-chemotherapy foot infection: chemotherapy often causes a decrease in white blood cells, the body’s immune system decreases, which can easily lead to infectious diseases, such as foot viral infections can appear after the cluster blisters, fungal infections can also appear after the blisters performance. 2. Skin side effects of chemotherapeutic drugs: some chemotherapeutic drugs can lead to skin side effects such as hand-foot syndrome, for example, capecitabine, 5-fluorouracil, etc. Hand-foot syndrome is often manifested as abnormal sensation of hands and feet, numbness of the hands and feet, erythema of the skin, desquamation, and some patients may have oozing, blisters, pain and other manifestations. 3. Allergy to chemotherapy drugs: some patients are allergic to chemotherapy drugs, which can lead to itching, peeling, erythema, blisters and other allergic manifestations. Blisters on the feet after chemotherapy may also have other reasons, such as patients with eczema and other skin diseases, it is recommended that patients under the guidance of the doctor to find the cause of the disease, symptomatic treatment.