Frequent closed mouth acne is recommended to visit a dermatologist as soon as possible, and the common clinical treatments include medication and general treatment. Acne vulgaris is a mild form of acne, a chronic inflammatory disease that occurs in the sebaceous gland units of hair follicles. Commonly used clinical medications for acne include retinoids, benzoyl peroxide, and the antibiotics erythromycin ointment and fusidic acid cream. General treatment includes choosing appropriate cleansing products, avoiding hand squeezing of lesions, avoiding late nights, and eating less oily and high sugar foods. If you have closed mouth acne, it is recommended that you go to a dermatology clinic as soon as possible and follow the doctor’s instructions for standardized treatment to ensure a good prognosis for the disease.