After prostate puncture biopsy, you should pay attention to rest, pay attention to vital signs as well as urinary symptoms, and prevent complications such as bleeding and infection. 1. Pay attention to rest: try to rest in bed within 24 hours after the puncture, reduce the activity of getting out of bed, and avoid strenuous activities in the lower back and abdomen within 3 weeks after the puncture. 2. Pay attention to vital signs and urinary symptoms: blood pressure and pulse should be measured hourly after puncture, and it can be changed to once every 2 hours if it is stable for 3 times in a row. Observe whether there are symptoms such as hematuria and perineal pain. 3. Prevention of bleeding: Bleeding is the most common complication after prostate puncture. If bleeding occurs after puncture, hemostatic drugs such as phenolsulfonyl ethylamine can also be applied as prescribed by the doctor. If there is blood seepage from the wound, you can change the dressing regularly and put pressure on the dressing. 4. Prevention of infection: prostate puncture is an invasive operation, and antibiotics such as levofloxacin can be used prophylactically for 3 to 4 days after the operation to prevent infection. If there are fever, chills, urinary frequency, urinary urgency and other symptoms of urinary tract infection should also be timely application of levofloxacin and other quinolone antibiotics. Patients are advised to consult a specialist and follow the doctor’s instructions for post-puncture care to prevent postoperative complications.