Due to each person’s different physique, and drug resistance, it is often difficult to determine the best time period for Dapoxetine to work, and the drug’s instructions recommend that men take it about 1-3 hours before sex for better results. Dapoxetine is a medication for the treatment of premature ejaculation in men, and its mechanism is to block or slow down nerve conduction in the body, thus improving premature ejaculation. It is often difficult to specify the best time period for Dapoxetine to work as each person’s body type tolerates the drug differently. This medication is taken as needed, only before sex, not without sex, and the instructions indicate that it is recommended for all male patients to take it about 1-3 hours before sex. The use of dapoxetine hydrochloride can cause adverse reactions such as headache, dizziness, nausea and diarrhea, which need to be taken care of. In addition, it is necessary to know the contraindications of the drug, such as the fact that the drug is contraindicated in people with a known allergy to the product, in patients with a significant pathological condition of the heart, and in patients with moderate and severe hepatic injury. The drug should also not be used in conjunction with thioridazine, strong cytochrome P450 3A4 inhibitors, and monoamine oxidase inhibitors. It is recommended that patients strictly follow the doctor’s instructions to use the drug, do not change the dose of the drug without authorization or private abuse of the drug, after the use of the drug should also pay attention to the observation of drug reactions, if any discomfort promptly consult a doctor.