Thigh pain and weakness, squatting difficulty may be due to thigh muscle strain, osteoarthritis, lumbar disc herniation, the cause is different, the treatment is different. 1. Thigh muscle strain: thigh muscle strain patients can appear thigh pain and weakness, squatting difficulties, in addition, the affected area will also appear red, swollen, pain, treatment should be based on rest, but also through the cold compresses, compression bandage, elevation of the affected limb and other ways to reduce edema. 2. Osteoarthritis: Osteoarthritis is a chronic joint disease with degenerative changes of articular cartilage and secondary osteomalacia, if the disease violates the knee and hip joints, patients may have symptoms of thigh pain and weakness, and difficulty in squatting, and the treatment should be based on proper rest, avoiding weight-bearing, and the use of diclofenac sodium for pain relief, and also the use of chondroitin sulphate and other medicines for treatment. 3. Lumbar disc herniation: lumbar disc herniation is a kind of lumbar disc degeneration, compression of the spinal nerve root caused by the disease, patients with this disease can appear thigh pain and weakness, squatting difficulty symptoms, treatment, patients can wear a waist cuff for support, and can use mannitol dehydration, to reduce the edema of the nerve root, and can be used to ibuprofen, celecoxib, and other medications to relieve pain. In addition to the above diseases, other diseases can also lead to the symptoms of thigh pain and weakness, difficulty in getting up and squatting, and it is recommended to consult a doctor in time to find out the cause, so as not to delay the condition.