The cause of rheumatism is still unclear, and may be related to immune response, genetic factors and infectious factors. 1. Immune response: the dysfunction of the immune system in the body leads to abnormal activation of B cells and T cells, production of autoantibodies and secretion of a large number of inflammatory cytokines, which leads to specific immune response of the body, causing different degrees of damage to various tissues and organs. 2. Genetic factors: some genes related to the occurrence of rheumatic diseases have been found, and epidemiology shows that first-degree relatives of patients with rheumatic diseases are more likely to suffer from the disease. 3. Infectious factors: Antigens or superantigens created by microorganisms can directly or indirectly trigger or set off the body’s immune response. If the diagnosis of rheumatism is confirmed, it is recommended to seek early medical attention and standardized treatment to reduce the adverse effects of the disease through “early detection, early diagnosis and early treatment”.