Nodules on the lateral side of the thigh can be felt as the following diseases: first, benign tumors occurring in the subcutaneous tissue, commonly lipoma or fibroma, which can be manifested by tenderness. Physical examination will also feel the lesion surface smooth, clear boundary, good mobility, and the patient will also have pain, commonly occurs in the subcutaneous tissue of some diseases. If the lesion increases gradually or there is obvious discomfort, surgical treatment can be chosen. Secondly, due to varicose veins, localized formation of venous sinus, and even the formation of thrombus embolus, also known as thrombophlebitis. The patient will also show pain, localized pressure pain, and even lead to skin necrosis, if necessary, also need to choose surgical treatment. The causes of varicose veins are related to prolonged upright position and weight bearing, and mild cases can be treated by wearing compression stockings.