Coronary heart disease cannot be cured by oral medication, and the medication modality can only alleviate the symptoms to a certain extent. Coronary heart disease is an incurable disease, the patient’s pathogenesis is based on the gradual emergence of atherosclerosis, because coronary artery sclerosis can not be reversed, so coronary heart disease can not be completely cured, and coronary artery atherosclerosis may be further progression, with the possibility of myocardial infarction and heart failure. Drug therapy is the basis for the treatment of coronary heart disease, including aspirin, atorvastatin, resuvastatin, metoprolol, isosorbide nitrate and other medications. The medications can improve the patient’s symptoms and slow the progression of the disease, and they cannot completely reverse the progression of coronary atherosclerosis, but they can reduce the incidence of malignant diseases, such as heart failure and heart infarction. For patients with serious conditions, the need for coronary angiography, some patients need stenting, or coronary artery bypass graft. Coronary heart disease patients should be timely hospital consultation, receive regular treatment and should follow the doctor’s instructions to take medication, reduce the incidence of myocardial infarction and other diseases, prolong the patient’s survival time.