Gastroscopy and colonoscopy, compared with colonoscopy will be more painful, but the specific degree of pain varies from person to person. 1. Gastroscopy: When doing gastroscopy, the gastroscope will pass through the throat, and stimulation of the throat will cause nausea, vomiting and other discomforts of the pharyngeal reflexes, and when the gastroscope moves inside the stomach, it may stimulate the gastric mucosa, and nausea and other discomforts will occur, but it will not be too painful during the gastroscopy. 2. Enteroscopy: when doing enteroscopy, the mirror will pass through the sigmoid colon, splenic flexure and other places, stimulation of these places will have tugging pain, such as abdominal discomfort, but it will not be too painful. Therefore, compared with gastroscopy and colonoscopy, colonoscopy will be more painful, and the details will vary from person to person. If the results of gastroscopy and colonoscopy are abnormal, it is recommended to consult a doctor in a timely manner to clarify the cause of the disease and carry out targeted treatment or therapy.