A particularly white patch in the middle of the nose may be caused by vitiligo, pityriasis alba, anemia nevus and other diseases. 1. Vitiligo: A lack of melanin within the skin can lead to vitiligo, which causes white patches to appear at the corners of the mouth, nose, around the eyes and other areas where the sun tends to shine. The edges of these white patches are usually clearer, smooth in texture, and there is usually no itching, peeling or other symptoms. 2. Leukofurfury: also called facial pityriasis versicolor, it occurs on the face, and may also lead to the appearance of round or oval pale white patches on the skin in the middle of the nose, which is usually covered with chaff-like scales. 3. Anemic nevus: If the catecholamines in the body cause local capillary contraction, it may also cause the phenomenon of ischemic whitening of the skin in the nose area, and after a long time, white patches will be formed. Anaplastic nevus, leprosy white spots, etc. may also lead to the phenomenon of whitening in the middle of the nose, it is recommended that the patient consult a doctor in a timely manner, after a clear diagnosis of the cause of the disease, and actively treat it, so as not to delay the condition.